ࡱ> UWT)` RJbjbjUU2P??s$$ `````;U a$Q"h$b]i;;ii``G i,``i<`T FuR] 0 ,%%<%<iiiiiiiiii iiii$$$ $$$$$$ wmYYe^;N[vxvzuhQe zW,gOo`h z TyuirSf[ Ne12g2e-12g17ehT+g N N k)Y NHS6-9 N0Wp+}ё/n!h:SN1B-311 z{N Biochemical sciences study the structure of the individual complex molecules that make up all living organisms, as well as the impressive network of chemical processes that are the essence of life. Biochemists explore the molecular basis of how bacteria, algae and plants eat incident solar radiation (sunlight) to produce sugar and carbohydrate reserves. Biochemistry helps us understand diseases of plants and animals in order to correct deficiencies through genetic engineering and new agro-chemicals and pharmaceuticals. As the foundation of the life sciences, biochemistry contributes more and more to the well-being of the worlds population and to societys economic growth. This Biochemistry grad course will provide you with a solid grounding in biology, chemistry, molecular- and systems-biology. Throughout the course, you will have the opportunity to supplement your classroom learning with a significant amount of English discussion in small-group innovation teams. This course will allow you to become more acquainted with specialized techniques and high-performance equipment, preparing you to move on to the fields of modern biochemistry: proteomics, genomics, molecular biology, genetic engineering, integrated metabolism, structural biochemistry, protein engineering and molecular modeling. During the course, you even have the opportunity to contribute to the advancement of scientific knowledge by participating in cutting-edge problem analysis, brain-storming, innovation, research and invention as you complete a three-week long Innovation Research Project with some of the worlds leading researchers. Advanced training via Biochemistry can help you prepare for careers in industrial, pharmaceutical, agri-food, clinical or research laboratories. You can also choose to study medicine, law, business or go on to teaching or postdoctoral studies. By focusing this course on a variety of subjects, such as the analysis of detailed aspects of molecular structures and the study of the integration of metabolism in whole organismal systems, this broad, basic background helps prepare you for a number of different work environments: teaching and research in an academic setting; research and administration in the biotechnology or pharmaceutical industry; or health-related disciplines in the public or private sector. Students with undergraduate education in the Life Science areas are welcome to take this course for credit: entomology, animal models of human disease, bioenergetics and metabolism, cancer biology, crop improvement, developmental genetics, growth and development, host resistance, membrane proteins, molecular biology of plants, viruses, bacteria and parasites, molecular biopharming in transgenic plants, protein farming, molecular genetics, molecular therapeutics, nanotechnology, neuromuscular disease, obesity, oral vaccines, physical biochemistry, protein chemistry, protein structure-function relationships, proteomics, RNA metabolism, signal transduction, or structural biology, just to name a few. The course will consist of Lectures, Discussion Groups, Seminars, and Invention Trios. Teachers: Prof. Illimar Altosaar, University of Ottawa, CANADA Prof. Wei-Jun Yang, Zhejiang University, CHINA Dr. Jin-Shu Yang, Zhejiang University, CHINAYef[eS hT!kYef[Q[Yl1Introduction to Biochemistry 2014-2020, Vision of the futureProtein engineering: Immunoglobulin structure-function relations2Immunological defence mechanismsadaptive and innate host-defence3Genomicsmolecular drive, evolution (Kyoto Prize), synthetic organisms4Biologics and biopharmaceutical industriesOr why Mitsubishi-Tanabe acquired Medicago Inc. - recombinant protein expression systems, From Escherichia to Oryza5Lipids and Lipid-Protein InteractionsMembranes, Lipid Transfer Proteins6Organellar proteomicsCase study of Tryptophan-rich domains7Systems biology: from oceans to vitaminsproteomics and bioinformatics8Amino acid chemistry is back in vogueOpti-gest and trifluoroacetic acid hydrolysis.Se.s Virdi V, Coddens A, De Buck S, Millet S, Goddeeris BM, Cox E, De Greve H, Depicker A. 2013. Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection. Proceedings of the National Academy of Sciences of the United States of America 110 (29): 11809-11814 DOI: 10.1073/pnas.1301975110 Afshar M, Gallo, Richard L. 2013. Innate immune defense system of the skin. Veterinary Dermatology 24 (1): 32-+ DOI: 10.1111/j.1365-3164.2012.01082.x Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR, Hetzer, MW. 2013. Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures. Cell 154 (5): 971-982 DOI: 10.1016/j.cell.2013.07.037 Diedrich JK, Pinto AFM, Yates JR. 2013. Energy Dependence of HCD on Peptide Fragmentation: Stepped Collisional Energy Finds the Sweet Spot. J of the American Society for Mass Spectrometry 24 (11): 1690-1699 DOI: 10.1007/s13361-013-0709-7 Anderson OD, Huo NX, Gu YQ. 2013. The gene space in wheat: the complete gamma-gliadin gene family from the wheat cultivar Chinese Spring. Functional & Integrative Genomics 13(2): 261-273 DOI: 10.1007/s10142-013-0321-8 Sabalza M, Vamvaka E, Christou P, Capell T. 2013. Seeds as a Production System for Molecular Pharming Applications: Status and Prospects. Current Pharmaceutical Design 19(31): 5543-5552. Pauly, Anneleen et al., 2013. Wheat (Triticum aestivum L. and T. turgidum L. ssp durum) Kernel Hardness: I. Current View on the Role of Puroindolines and Polar Lipids. Comprehensive Reviews in Food Science and Food Safety 12(4): 413 -426. *4<>@HJ xz|  ˿߿߶˗uuuhh#KCJPJh)ph#KCJPJh#KCJPJh#K h#Ko(h#KhPJh#KhmPJo( h#KPJo(h#Kh#KPJh6B*aJo(phhhaho(hahao( ho(h:fh,5CJaJo(h{ h,5CJaJo(.*4>@J]GG$$Ifa$gdlkd$$IfTl0!/W t0!6 44 layt T$$Ifa$gd,l$a$gd,J{ee$$Ifa$gd,lkds$$IfTl0!/W t0!6 44 layt T {eeRRRRRR$Ifgd#Kl$$Ifa$gd,lkd$$IfTl0$!/a t0!644 layt T  z|hRR$$Ifa$gd,lkdY$$IfTl0!/W t0!6 44 layt T$Ifgd#Kl >kd$$IfTl4\ !/3  t0!6 44 layt#KT$$Ifa$gd,l ;%$$Ifa$gd,lkde$$IfTl4\ !/3  t0!6 44 layt#KT$d$Ifa$gd#Kl%kd$$IfTl4\ !/3  t0!6 44 layt#KT$d$Ifa$gd#Kl$$Ifa$gd,l$b$d$Ifa$gd#Kl$$Ifa$gd,l#$abcfo ./QRSVkl jlnz2 / !HH'IIJԿhahaKHaJmH o(sH U(hahaKHPJaJmHnH sHtH (hahaKHPJaJmH nH sH tH (hahaKHPJaJmHnH sHtH  ho(h#KCJPJ h#Ko(h#Kh)ph#KCJPJhh#KCJPJ3bcdfT>>%$d$Ifa$gd#Kl$$Ifa$gd,lkd$$IfTl4\ !/3  t0!6 44 layt#KT ;%%$$Ifa$gd,lkd0$$IfTl4\ !/3  t0!6 44 layt#KT$d$Ifa$gd#Kl /RST;%$$Ifa$gd,lkd$$IfTl4\ !/3  t0!6 44 layt#KT$d$Ifa$gd#KlTVl%kdb$$IfTl4\ !/3  t0!6 44 layt#KT$d$Ifa$gd#Kl$$Ifa$gd,l$d$Ifa$gd#Kl$$Ifa$gd,lT>>%$d$Ifa$gd#Kl$$Ifa$gd,lkd$$IfTl4\ !/3  t0!6 44 layt#KTlnxz;%%$$Ifa$gd,lkd$$IfTl4\ !/3  t0!6 44 layt#KT$d$Ifa$gd#Klz-  !HIRJJ$$Ifa$gdal"$7d$1$If^7`a$gdal De Buck S, Nolf J ,De Meyer T, Virdi V, De Wilde K, Van Lerberge E, Van Droogenbroeck B, Depicker A. 2013. Fusion of an Fc chain to a VHH boosts the accumulation levels in Arabidopsis seeds. Plant Biotechnology J 11 (8): 1006-1016. Pinheiro C, Sergeant K,Machado CM, Renaut J, Ricardo CP. 2013. Two Traditional Maize Inbred Lines of Contrasting Technological Abilities Are Discriminated by the Seed Flour Proteome. J Proteome Research 12 (7): 3152-3165 DOI: 10.1021/pr400012t. Nelson D, Cox MM. 2008. Lehningers Principles of Biochemistry, Fifth Edition. W.H. Freeman and Company, New York. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2008. Molecular Biology of the Cell, Fifth Edition. Garland Science, New York. JJJJJJ h,ha1 h,o(hhahaKHaJmH o(sH hahaKHaJmH sH JJJJ{vtgd,kd-$$IfTlN 0!/W t0!6 44 layt T0182P. A!"#$%S q$$If!vh5/5W#v/#vW:Vl t!6 ,5/5Wyt Tq$$If!vh5/5W#v/#vW:Vl t!6 ,5/5Wyt Tq$$If!vh5/5a#v/#va:Vl t!6,5/5ayt Tq$$If!vh5/5W#v/#vW:Vl t!6 ,5/5Wyt T$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KT$$If!vh5/535 5 #v/#v3#v :Vl4 t!6 +,5/535 yt#KTq$$If!vh5/5W#v/#vW:VlN t!6 ,5/5Wyt TJ@J ,cke $1$a$ CJKH_HaJmH nHsH tH$A@$ ؞k=W[SOBi@B nfh C D G L O P Q S $bcdf /RSTVl67<=- {rpqru00 0 0 0 0 0 0 0 0 00 000000000000 0 00 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 00 00000000000 0 00 %ABGTU[= > L bcRS67<={rpqru00$ʑ00' ȑ00' 00 00 00 00 00 00+ 00 00 00  @00T 070800300 00 00R0?000R0A000R0C000 R0E00 0 R000 0 R @0 ʑ00tDʑ00  ʑ00  00 @0D=3 0G0@000 0000ʑ0'0@00G0@0  @0 00JJ&b TzJJ !"#'J8@0(  B S  ? OLE_LINK2uu?@UY!%]g    V`$=8=V]lr$ /[bFN,9  Ru%A=  sRz{2u%@ABZ > K L P Q S $f /l7=uC{h^h`o(. H\^H`\hH) \^`\hH. \^`\hH. 4\^4`\hH)  \^ `\hH. | \^| `\hH.  \^ `\hH) \^`\hH.C,.9        _^H 4cw #&~XH]Np$V&ua'I(p(5-*.22L2M 8tH: <R|B+CO{DTFHT;I K|KAdMW{MNWPP D G L O P Q S $bcdf /RSTVl67=pqu@ @@$@@X sPP@PP0@PP8@P@UnknownG:Ax Times New Roman5Symbol3& :Cx Arial;5 |8ўSOSimHei]5  N[_GB2312Arial Unicode MS7&@Calibri;([SOSimSun qhg'ug  . .!-!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[rdff 2qHP ?,2wmYYe^;N[vxvzuhQe zW,gOo`hDellDell Oh+'0 , L X dpx,ʦоȫӢĿγ̻ϢDellNormalDell29Microsoft Office Word@hx@mB@ff՜.+,0 X`lt| . f'   !"#$%&'(*+,-./023456789:;<=>?@ABCEFGHIJKMNOPQRSVRoot Entry FpuXData )1Table1+%WordDocument2PSummaryInformation(DDocumentSummaryInformation8LCompObjm  FMicrosoft Office Word ĵ MSWordDocWord.Document.89q